For large vessels such as the aorta and its branches, the dose can be as low as 0.1 mmol / kg of body mass. Over 450 million doses have been administrated worldwide from 1988 to 2017. Gadolinium(III) containing MRI contrast agents (often termed simply "gado" or "gad") are the most commonly used for enhancement of vessels in MR angiography or for brain tumor enhancement associated with the degradation of the blood–brain barrier. T 1-weighted images, left image without, right image with contrast medium administration
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